# Current Approaches of Nuclear Molecular Imaging in Breast Cancer

**Authors:** Laura Schäfer, Betül Altunay, Amelie Heesch, Thiemo van Nijnatten, Sofia Vaz, Malik Eid Juweid, Felix Manuel Mottaghy

PMC · DOI: 10.3390/cancers17132105 · Cancers · 2025-06-23

## TL;DR

This review discusses recent advances in nuclear molecular imaging for breast cancer, focusing on how these techniques improve diagnosis and treatment.

## Contribution

The paper provides an updated overview of clinical investigations on nuclear molecular imaging in breast cancer from the past 2–3 years.

## Key findings

- Nuclear molecular imaging enables precise detection of breast cancer tumors and metastases using radiolabeled probes.
- Recent studies highlight the integration of imaging modalities into radioligand therapy and theragnostic strategies for breast cancer.
- The review emphasizes the enhanced diagnostic and therapeutic value of these imaging techniques in clinical practice.

## Abstract

Breast cancer (BCa) is the most prevalent malignancy among women worldwide, representing a significant public health challenge due to its complex biology, varied subtypes, and the need for tailored therapeutic strategies. Early and accurate diagnosis is critical for improving patient outcomes. Molecular imaging has emerged as a transformative approach in oncology, enabling the visualization of biological processes at the molecular and cellular levels. This technique utilizes radiolabeled probes to target specific biomarkers associated with cancer, facilitating the detection of tumors and metastases with greater precision.

In this narrative review, we aim to summarize recent advancements in nuclear molecular imaging techniques and their applications in BCa management. The main focus of this review is on the most relevant clinical investigations from the past 2–3 years that highlight the enhanced diagnostic and therapeutic value of these imaging modalities. A variety of radiolabeled probes introduced in molecular imaging is explored, detailing their roles in the accurate diagnosis and characterization of BCa, as well as their integration into radioligand therapy and theragnostic strategies.

## Linked entities

- **Diseases:** breast cancer (MONDO:0004989)

## Full-text entities

- **Diseases:** Breast Cancer (MESH:D001943)

## Full text

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## Figures

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## References

154 references — full list in the complete paper: https://tomesphere.com/paper/PMC12249193/full.md

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Source: https://tomesphere.com/paper/PMC12249193