# Prurigo Nodularis at Ultra-High-Frequency Ultrasound

**Authors:** Alessandra Michelucci, Corrado Tagliati, Flavia Manzo Margiotta, Giorgia Salvia, Marco Fogante, Giulio Rizzetto, Antonio Corvino, Elisa Molinelli, Annamaria Offidani, Oriana Simonetti, Marco Romanelli, Valentina Dini

PMC · DOI: 10.3390/diagnostics15131624 · Diagnostics · 2025-06-26

## TL;DR

This paper presents the first ultra-high-frequency ultrasound images of prurigo nodularis, offering new insights into its features for better diagnosis.

## Contribution

The first reported ultra-high-frequency ultrasound images of prurigo nodularis.

## Key findings

- Ultrasound showed hypoechoic dermal and hyperechoic epidermal thickening.
- Lesion hypervascularity was observed via color-Doppler ultrasound.

## Abstract

Here, we describe the case of a 48-year-old female patient with prurigo nodularis, where B-mode and color-Doppler ultrasound of one nodule was performed; this revealed hypoechoic dermal and hyperechoic epidermal thickening with lesion hypervascularity. To the best of our knowledge, no previous published articles have reported ultra-high-frequency ultrasound images of this disease, so this case can encourage prurigo nodularis studies in order to better assess ultrasound features and their usefulness in supporting clinical diagnosis and in distinguishing prurigo nodularis from other diseases.

## Linked entities

- **Diseases:** prurigo nodularis (MONDO:0026045)

## Full-text entities

- **Diseases:** Prurigo Nodularis (MESH:D011536)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12248776/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12248776/full.md

---
Source: https://tomesphere.com/paper/PMC12248776