# Best Supportive Care for Patients with Chronic Lymphocytic Leukemia: Relevance of Cancer Screening and Immunizations

**Authors:** Vanthana Bharathi, Alessandra Ferrajoli

PMC · DOI: 10.3390/cancers17132093 · Cancers · 2025-06-23

## TL;DR

This paper reviews how supportive care strategies like vaccines and cancer screenings can improve health outcomes for chronic lymphocytic leukemia patients.

## Contribution

The paper provides evidence-based recommendations for long-term health maintenance in CLL patients.

## Key findings

- Timely vaccinations and cancer screenings can reduce infections and detect cancers early in CLL patients.
- Lifestyle modifications and tailored preventive strategies improve quality of life and reduce hospitalizations.
- Immune dysfunction in CLL increases susceptibility to infections and secondary cancers.

## Abstract

Chronic lymphocytic leukemia (CLL) is a type of blood cancer that affects B cells, and it is typically seen in older adults and often leads to weakened immune system. With newer treatments helping people live longer, it is important to shift the focus on health maintenance care. This review explores how supportive care strategies such as vaccines, cancer screenings, and healthy lifestyle changes can help people with CLL stay healthier and avoid infections and detect cancers at earlier stages. The article emphasizes the need for timely vaccinations, cancer screenings, and tailored preventive strategies. These steps can improve quality of life, decrease morbidity, and reduce the risk of hospitalizations. Our goal is to provide healthcare providers with practical recommendations to enhance long term care for people living with CLL.

Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in the Western world, predominantly affecting older individuals. Advances in targeted therapies have extended survival, shifting the clinical focus toward the management of chronic health challenges. Patients with CLL often experience immune dysfunction due to both the disease and its treatments, resulting in an increased susceptibility to infections and second primary malignancies. This review outlines evidence-based strategies for preventive care in CLL, including age-appropriate cancer screenings, routine immunizations, and lifestyle modifications. By emphasizing proactive health maintenance, this article aims to support clinicians in delivering comprehensive, long-term care for patients with CLL.

## Linked entities

- **Diseases:** Chronic lymphocytic leukemia (MONDO:0004948)

## Full-text entities

- **Diseases:** leukemia (MESH:D007938), infections (MESH:D007239), CLL (MESH:D015451), immune dysfunction (MESH:D007154), Cancer (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

54 references — full list in the complete paper: https://tomesphere.com/paper/PMC12248605/full.md

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Source: https://tomesphere.com/paper/PMC12248605