# Lowback Pain Management with a Combination of Uridine Triphosphate, Cytidine Monophosphate, and Hydroxocobalamin: A Systematic Review and Meta-Analysis

## TL;DR

This paper reviews and analyzes the effectiveness of combining uridine triphosphate, cytidine monophosphate, and hydroxocobalamin for managing low back pain.

## Contribution

The study introduces a novel combination of neurotrophic substances for low back pain treatment and evaluates its efficacy through a systematic review and meta-analysis.

## Key findings

- The combination of uridine triphosphate, cytidine monophosphate, and hydroxocobalamin may support spinal nerve regeneration.
- The treatment shows potential as an anabolic precursor in managing low back pain.
- The meta-analysis suggests a possible role for these substances in symptomatic relief of low back pain.

## Abstract

Low back pain is a common complaint. This syndrome comprehends different underlying mechanisms, which are difficult to differentiate in a timely manner only through semiotic, laboratory, and imaging resources available in an emergency setting. Such circumstances make practitioners prone to an initial symptomatic approach in the form of medications (non-steroid anti-inflammatory drugs, analgesics, muscle relaxants) or local procedures (local heat, massage). Peripheral neurotrophic substances, such as pyrimidine nucleotides (uridine triphosphate and cytidine monophosphate) combined with vitamin B12 (hydroxocobalamin), have been used as anabolic precursors able to provide spinal nerve roots with triggering elements useful for nerve and glial cells regeneration, once a likely spinal compression mechanism is contained. The authors performed a systematic review and meta-analysis with the above combination with the aim of better determining its role in low back pain management.