# Mechanisms underlying anxiety in Rett Syndrome: Translational insights from preclinical findings

## TL;DR

This paper explores how Rett Syndrome can provide insights into anxiety mechanisms, particularly focusing on serotonin and the HPA axis.

## Contribution

The study highlights the understudied role of Mecp2 mutations in HPA axis function and their potential link to anxiety in Rett Syndrome.

## Key findings

- Serotonin's role in anxiety mechanisms in Rett Syndrome is complex.
- Mecp2 mutations alter HPA axis function, which is not well understood in Rett Syndrome.
- Rett Syndrome may help understand anxiety in individuals with early life stress.

## Abstract

•The role of serotonin in mechanisms of anxiety in Rett syndrome appears complex.•Mecp2 mutation alters HPA axis function but this is understudied in Rett syndrome.•Rett syndrome may inform understanding of anxiety in those with early life stress.

The role of serotonin in mechanisms of anxiety in Rett syndrome appears complex.

Mecp2 mutation alters HPA axis function but this is understudied in Rett syndrome.

Rett syndrome may inform understanding of anxiety in those with early life stress.