# Genomic characterization of multidrug-resistant Escherichia coli with PBP3 insertions carrying blaNDM-5 carbapenemase isolated from infants in Kenya

## TL;DR

This study reports on drug-resistant E. coli strains found in infants in Kenya, which could impact how patients are treated.

## Contribution

The study identifies a specific genetic feature in E. coli linked to drug resistance in infants.

## Key findings

- Carbapenem-resistant E. coli ST46 and 167 strains were isolated from infants in Kenya.
- The isolates carried blaNDM-5 and a PBP3 insertion, indicating resistance mechanisms.
- The findings suggest implications for managing patients with these resistant strains.

## Abstract

We report on carbapenem-resistant Escherichia coli ST46 and 167 strains isolated from fecal samples of 4- and 8-month-old infants, respectively, in Kenya, collected at discharge after more than 4 days of hospitalization. The isolates carried blaNDM-5 carbapenemase and a PBP3 (333YRIN/K334) insertion. This finding has implications for patient management.