# Chromosomal and extrachromosomal replicons of a multidrug-resistant zoonotic Staphylococcus ureilyticus strain RSM-JSascm isolated from cow milk in Western Uganda, sub-Saharan Africa

## TL;DR

This paper reports the genome of a multidrug-resistant Staphylococcus ureilyticus strain from cow milk in Uganda, revealing its chromosomal and plasmid structure and resistance genes.

## Contribution

The study provides the first detailed genomic analysis of a multidrug-resistant Staphylococcus ureilyticus isolate from sub-Saharan Africa.

## Key findings

- The isolate's chromosome contains 2,534 coding sequences and multiple RNA genes.
- Three plasmids were identified, carrying antimicrobial resistance genes.
- CRISPR arrays were found in the chromosome, suggesting potential for adaptive immunity.

## Abstract

Staphylococcus ureilyticus is a less-studied pathogen with zoonotic and antimicrobial resistance (AMR) potential. We sequenced a bovine isolate and recovered four replicons, a chromosome with 2,534 coding sequences (CDS), 51 transfer RNAs (tRNA), four ribosomal RNA (rRNA) genes, and two CRISPR arrays, along with three plasmids, harboring AMR genes.