# The genome sequence of varicella-zoster virus (Varicellovirus humanalpha3) obtained by metagenomics from a patient presenting with an exanthem rash

**Authors:** Sebastian Musundi, Dorcas Okanda, Arnold Lambisia, John Mwita Morobe, Eric Muthanje, Lynette Isabella Ochola-Oyier, Daniel P. Carter, Charles N. Agoti, John Kiiru, George Githinji

PMC · DOI: 10.1128/mra.00248-25 · 2025-06-10

## TL;DR

This paper presents a partial genome sequence of varicella-zoster virus from a patient in Kenya, providing insights into its genetic classification.

## Contribution

The study reports a novel partial genome sequence of varicella-zoster virus from a clinical sample in Kenya.

## Key findings

- The virus isolate was classified into varicella-zoster virus clade 5 through phylogenetic analysis.
- The genome was obtained using metagenomic sequencing from a skin lesion sample.

## Abstract

Here, we report a partial genome sequence of varicella-zoster virus, recovered through metagenomic sequencing from a skin lesion sample collected from a 31-year-old male from Mombasa, Kenya, in August 2024. Phylogenetic analysis placed this isolate in varicella-zoster virus clade 5.

## Linked entities

- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Diseases:** skin lesion (MESH:D012871), exanthem rash (MESH:D005076)
- **Species:** Homo sapiens (human, species) [taxon 9606], Human alphaherpesvirus 3 (Varicella-zoster virus, no rank) [taxon 10335]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12243526/full.md

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Source: https://tomesphere.com/paper/PMC12243526