Altered upper respiratory tract microbiota in laryngeal cough attributed to lung yin deficiency and the modulatory effects of Yangyin Qingfei Oral Liquid
Fei Yu, Jing Jin, Xinlai Jin, Xuchun Ding, Yafang Lou
TL;DR
This study shows that laryngeal cough linked to lung yin deficiency is associated with imbalanced upper respiratory tract microbiota, and treatment with Yangyin Qingfei Oral Liquid improves both microbiota and symptoms.
Contribution
The study introduces Yangyin Qingfei Oral Liquid as a treatment that modulates upper respiratory tract microbiota in laryngeal cough patients with lung yin deficiency.
Findings
Laryngeal cough patients had lower microbial abundance and diversity compared to healthy subjects.
Treatment with YYQFOL improved symptom scores and LCQ results more effectively than methoxyphenamine alone.
YYQFOL reduced harmful genera like Streptococcus and increased beneficial genera like Veillonella.
Abstract
This study investigates changes in upper respiratory tract microbiota in laryngeal cough patients with lung yin deficiency using high-throughput sequencing of the 16S rDNA gene. It also examines the modulatory effects of Yangyin Qingfei Oral Liquid (YYQFOL). We included 100 laryngeal cough patients and 65 healthy subjects, collecting throat swab samples for microbiota comparison. Patients were randomly assigned to a control group receiving methoxyphenamine capsules and an experimental group receiving YYQFOL and methoxyphenamine for 10 days. We assessed changes in microbiota, symptom scoring, and Leicester Cough Questionnaire (LCQ) results. Each group was divided into responders (R) and non-responders (NR). Patients with laryngeal cough had significantly lower microbial abundance and diversity than healthy subjects (p < 0.05). After treatment, symptom scores and LCQ results improved…
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Taxonomy
TopicsRespiratory and Cough-Related Research · Pediatric health and respiratory diseases · Mycobacterium research and diagnosis