# Familial Disseminated Comedones Without Dyskeratosis: A Case Report

## TL;DR

This paper reports a rare skin condition called DFCWD, which causes widespread comedones without certain skin cell abnormalities.

## Contribution

The paper contributes a new case report of DFCWD, highlighting its distinct clinical and histological features.

## Key findings

- DFCWD is characterized by widespread comedonal eruptions on the trunk and face.
- The condition lacks histopathological features like dyskeratosis or acantholysis.
- Its autosomal dominant inheritance supports its classification as a distinct disorder.

## Abstract

Disseminated familial comedones without dyskeratosis (DFCWD) is a rare autosomal dominant genodermatosis characterized by widespread comedonal eruptions, predominantly affecting the trunk and face, in the absence of histopathological features such as dyskeratosis or acantholysis. While it exhibits clinical overlap with other entities within the spectrum of familial comedonal disorders, its unique histological features and inheritance pattern support its classification as a distinct clinical entity. Due to the limited number of reported cases, its phenotypic spectrum, natural history, and underlying molecular mechanisms remain poorly understood.