Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice
Sara Bitarafan, Alyssa F. Pybus, Felix G. Rivera Moctezuma, Mohammad Adibi, Tina C. Franklin, Annabelle C. Singer, Levi B. Wood
TL;DR
This study shows how different sensory flicker frequencies and durations affect gene activity in the brains of mice with Alzheimer's disease.
Contribution
The study reveals how AV flicker frequency and duration specifically control transcriptional profiles in brain regions affected by AD.
Findings
All flicker frequencies rapidly activated immune genes in the visual cortex within 0.5 hours.
Hippocampal 20 Hz flicker activated genes related to mitochondria and synaptic translation.
10 Hz flicker suppressed hippocampal genes linked to neurotransmitter activity.
Abstract
Current clinical trials are investigating gamma frequency sensory stimulation as a potential therapeutic strategy for Alzheimer's disease (AD); yet, we lack a comprehensive picture of the effects of this stimulation on multiple aspects of brain function. We previously showed that exposing mice to visual flickering stimulation increased mitogen activated protein kinase and nuclear factor kappa-light-chain-enhancer of activated B cells signaling in the visual cortex (VC) in a manner dependent on the duration and frequency of stimulation. Because these pathways control multiple neuronal and glial functions, here we aimed to define the transcriptional effects of different frequencies and durations of audiovisual flicker (AV flicker) stimulation on multiple brain functions. Within the VC, we found that all stimulation frequencies caused fast activation of a module of immune genes within 0.5…
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Taxonomy
TopicsOlfactory and Sensory Function Studies · Neuroinflammation and Neurodegeneration Mechanisms · Hearing, Cochlea, Tinnitus, Genetics