# Unexpected Digit: Isolated Acrometastasis to the Fifth Finger in Advanced Lung Cancer

**Authors:** Zakaria Alameddine, Parima Saxena, Micha Gooden, Farish Mohamed, Elvira Neculiseanu

PMC · DOI: 10.7759/cureus.85646 · 2025-06-09

## TL;DR

This paper reports a rare case of lung cancer spreading to the fifth finger, highlighting treatment strategies and the need for a multidisciplinary approach.

## Contribution

The novelty lies in presenting an isolated acrometastasis case without additional bone metastases in advanced lung cancer.

## Key findings

- Isolated acrometastasis occurred in the fifth finger without other bone metastases in a stage IV lung cancer patient.
- Multidisciplinary management combining surgery, radiation, and systemic treatment is emphasized for such cases.
- The paper discusses potential mechanisms behind acrometastatic spread in lung cancer.

## Abstract

Acrometastasis is a rare manifestation of metastatic disease that affects the distal extremities and can occur as a complication of non-small-cell lung cancer. It is often associated with advanced disease and may coincide with other skeletal or systemic metastases. Management options typically include a combination of surgical intervention, radiation therapy, and systemic treatment. This report presents a case of an isolated acrometastatic lesion in the fifth digit of a patient with stage IV squamous cell carcinoma, without evidence of additional metastatic bone involvement. We explore diagnostic and therapeutic strategies for such presentations and emphasize the importance of a multidisciplinary approach in optimizing patient care. We also address the underlying pathophysiology and potential mechanisms contributing to acrometastatic spread.

## Linked entities

- **Diseases:** non-small-cell lung cancer (MONDO:0005233), squamous cell carcinoma (MONDO:0005096)

## Full-text entities

- **Diseases:** stage IV squamous cell carcinoma (MESH:D002294), Lung Cancer (MESH:D008175), metastases (MESH:D009362), non-small-cell lung cancer (MESH:D002289)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12240538/full.md

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Source: https://tomesphere.com/paper/PMC12240538