Estrogenic activity of mixtures in the Salish Sea: The use of high throughput toxicity data with chemical information from fish bile and other matrices
Maya Faber, C. Andrew James, Louisa B. Harding, Denis A. M. da Silva, Ruth M. Sofield
TL;DR
This study assesses estrogenic activity in chemical mixtures in the Salish Sea using high throughput toxicity data and identifies key chemicals responsible for this activity in fish bile and water.
Contribution
The study introduces novel thresholds for estrogenic activity in water and fish bile, and identifies key chemical drivers of this activity in mixtures.
Findings
Estrogenic mixture thresholds in water and fish bile were developed and validated using field data.
Estrone, 17β-estradiol, and estriol were identified as primary drivers of estrogenic activity in fish bile.
Bisphenol A was found to be a major contributor to estrogenic activity in mixtures.
Abstract
A subset of anthropogenic chemicals known as contaminants of emerging concern (CECs), are released into aquatic environments through human activities. CECs occur in mixtures, and some may share a common mode of action such as estrogen receptor agonism, which lead to reproductive disturbances in fish. In this study, the estrogenic activity of mixtures was assessed with in vitro high throughput data, which expanded the number of chemicals included in the evaluation. Data were compiled from 16 studies, analyzing 387 CECs (19 estrogen agonists detected), across various matrices including water, wastewater treatment plant effluent, fish and mussel tissue, and fish bile. Novel estrogenic mixture thresholds in water and bile were developed. In one application of the bile thresholds, field sites with elevated exogenous estrogenic activity were identified; thresholds were qualitatively validated…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsPharmaceutical and Antibiotic Environmental Impacts · Effects and risks of endocrine disrupting chemicals · Toxic Organic Pollutants Impact