# Colonic Diaphragm Disease Induced by Chronic Non-steroidal Anti-inflammatory Drug (NSAID)-Use Requiring Multiple Endoscopic Interventions: A Case Report

## TL;DR

A 51-year-old man with chronic NSAID use developed a rare colonic diaphragm disease requiring multiple endoscopic treatments.

## Contribution

Highlights a rare NSAID-induced gastrointestinal condition and the use of advanced endoscopic techniques for management.

## Key findings

- Chronic NSAID use can lead to colonic diaphragm disease with symptoms like abdominal pain and bleeding.
- Advanced endoscopic interventions, including stent placement and balloon dilation, were necessary to manage the stricture.

## Abstract

Non-steroidal anti-inflammatory drug (NSAID)-induced colonic diaphragm disease is an uncommon yet significant cause of gastrointestinal symptoms. We present a case of a 51-year-old male with chronic NSAID use who developed abdominal pain, weight loss, and gastrointestinal bleeding. Imaging and endoscopy revealed a short, benign-appearing stricture in the ascending colon consistent with diaphragm disease. The patient required multiple endoscopic interventions, including lumen-apposing metal stent placement and balloon dilation, to relieve the obstruction. This case underscores the importance of recognizing NSAID-induced colonic pathology and highlights the role of advanced endoscopic techniques in managing complex strictures.