# Multicentric infantile myofibromatosis with extensive visceral involvement in a newborn: case report

## TL;DR

This case report describes a rare tumor in a newborn with unusual symptoms and challenges in diagnosis.

## Contribution

The paper presents a rare case of multicentric infantile myofibromatosis with extensive visceral involvement in a newborn.

## Key findings

- Diagnosis was difficult and confirmed only after birth through pathology results.
- Visceral involvement is rare and considered a poor prognostic factor.
- Spontaneous regression is possible, suggesting a watchful waiting approach may be appropriate.

## Abstract

Infantile myofibromatosis, a rare soft tissue neoplasm that may present at birth or in early infancy, is the most common fibrous tumor of infancy and early childhood. Diagnosis could be challenging due to different clinical presentation. Very few cases are detected prenatally and visceral involvement is extremely rare.

We present a case of Disseminated Infantile Myofibromatosis with challenging prenatal ultrasound and misleading clinical presentation. Diagnosis was very difficult and confirmed by pathology results obtained after birth.

Visceral involvement constitutes a specific unfavorable prognostic factor but a watchful waiting approach would always be appropriate, since spontaneous regression and a favourable evolution are possible and age-related chemotherapy severe side effects and long-term sequelae are matter of concern.