# Sexual identity inequalities in the co-occurrence of poor mental health and health risk behaviours—a national cross-sectional study

**Authors:** Amal R. Khanolkar, Alexis Karamanos, Laia Becares

PMC · DOI: 10.1186/s12916-025-04236-2 · BMC Medicine · 2025-07-09

## TL;DR

Sexually minority adolescents face higher rates of poor mental health and risky behaviors, leading to increased self-harm and suicide attempts compared to heterosexual peers.

## Contribution

This study reveals higher co-occurrence of mental health problems and health risk behaviors among sexual minority adolescents and their stronger association with self-harm and suicide attempts.

## Key findings

- Mental health problems and health risk behaviors co-occur more frequently in sexual minority adolescents.
- Bisexual and gay/lesbian adolescents show significantly higher rates of self-harm and attempted suicide compared to heterosexual peers.
- Co-occurrence of mental health problems and health risk behaviors increases suicide risk independently of sexual identity.

## Abstract

Mental health problems (MHP, like depression/anxiety) and health and risk behaviours (HRBs) are more common among sexual minority adolescents (SMA) than in heterosexual peers. Limited studies have examined the co-occurrence of poor mental health and HRBs, if co-occurrence differs by sexual identity, and associated risks for self-harm and attempted suicide in adolescents.

This study included 10,233 adolescents aged 17 years (51% female/11% sexual minority) from the UK-wide Millennium Cohort Study. Sexual identity, MHP, seven HRBs (like regular smoking, drug use and sexual risk behaviour), self-harm and attempted suicide were self-reported. MHP were assessed using the strengths and difficulties questionnaire [SDQ] emotional symptoms subscale for depression/anxiety. We assessed associations between sexual identity and co-occurrence of MHP and HRBs using multinomial logistic regression. We estimated predicted probabilities for self-harm or attempted suicide based on sexual identity and MHP-HRB co-occurrence status using logistic regression models with appropriate interaction terms (between sexual identity and MHP-HRB co-occurrence status variables).

MHP prevalence was higher in gay/lesbian (48%) and bisexual (49%) adolescents compared to heterosexual peers (19%). Self-harm (bisexual, 64%; gay/lesbian, 53%; heterosexual, 19%) and attempted suicide (bisexual, 24%; gay/lesbian, 17%; heterosexual, 6%) prevalence were higher in SMA compared to heterosexual peers. Gay/lesbian and bisexual adolescents consistently had higher probability for MHP-HRB co-occurrence compared to heterosexual peers (example, for gay/lesbian individuals: RRR 3.16 [95% CI 2.1–4.68] for MHP-1HRB, RRR 3.54 [95% CI 2.06–6.08] for MHP- ≥ 3HRB, for bisexual adolescents: RRR 2.44 [95% CI 1.85–3.20] for MHP-1HRB, RRR 4.11 [95% CI 2.99–5.66] for MHP- ≥ 3HRB). MHP-HRB co-occurrence and sexual minority identity were independently associated with greater odds for self-harm or attempted suicide. SMA had higher probabilities of reporting self-harm than heterosexual peers with the same level of MHP-HRB co-occurrence. For example, 37.2% of heterosexual adolescents with MHP-1HRB reported self-harm. Corresponding numbers were twice as high in bisexual (75.7%) and gay/lesbian (77.9%) individuals. Similarly, 58.3% of heterosexual adolescents with MHP- ≥ 3HRBs reported self-harm, increasing to 84.6% in bisexual and 83.8% in gay/lesbian peers.

SMA are more likely to experience MHP-HRB co-occurrence, which is associated with substantially higher risks for self-harm and attempted suicide compared to heterosexual peers. Findings highlight the need for better public health policies to address MHP and associated comorbidities to reduce sexual identity-related health inequities in adolescence.

The online version contains supplementary material available at 10.1186/s12916-025-04236-2.

## Full-text entities

- **Genes:** CACNA1A (calcium voltage-gated channel subunit alpha1 A) [NCBI Gene 773] {aka APCA, BI, CACNL1A4, CAV2.1, DEE42, EA2}
- **Diseases:** Mental health problems (MESH:D000076082), Self-harm (MESH:D012652), anxiety (MESH:D001007), depression (MESH:D003866)

## Full text

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12239281/full.md

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Source: https://tomesphere.com/paper/PMC12239281