# Dishevelled-1 regulates global transcriptomic changes and associates with ETS1 transcription factor

## TL;DR

This study shows that DVL1 affects gene expression across the genome and partners with ETS1 to target specific genes in the nucleus.

## Contribution

The study identifies ETS1 as a transcription factor partner of nuclear DVL1, revealing its role in gene regulation.

## Key findings

- Modulating DVL1 expression leads to global transcriptomic changes.
- DVL1 binds to many genomic loci, as shown by ChIP-sequencing.
- ETS1 is identified as a transcription factor that interacts with nuclear DVL1.

## Abstract

Dishevelled (DVL) is a crucial component of the Wnt-signaling pathway and is vital for multiple physiological processes. Previously thought to have a classically cytoplasmic role, the discovery of DVL nuclear translocation reframed how it is viewed functionally. Although significant progress has been made in understanding the nuclear functions of DVL, further research is required to clarify its roles in transcriptional and epigenetic regulation. A key unresolved question is whether nuclear DVL1 associates with a transcription factor partner. We show here that modulation of DVL1 expression globally affects the transcriptomic landscape. Additionally, analysis of DVL1 ChIP-sequencing allowed us to map genome-wide binding sites, revealing the extensive reach of DVL1 binding. Integration of RNA-sequencing and ChIP-sequencing further revealed ETS1 as a transcription factor binding partner which targets nuclear DVL1 to specific genomic loci. These findings provide insight into the contribution of DVL1 in transcription and clarify aspects of its elusive nuclear function.

Currently, nuclear roles for DVL1 and its involvement in gene regulation remained unclear. Here the authors reveal that altering DVL1 expression significantly reshapes gene expression patterns across the genome and identify ETS1 as a key transcription factor that partners with nuclear DVL1, guiding it to specific genomic targets.