# Rare case report: non-mass invasive ductal carcinoma presenting with rectal and cervical lymph node metastasis as the initial symptom

**Authors:** Qiong Zhang, Zhifeng Xiong, Yuan Gao, Min Zeng, Huachao Yang, Gang Lyu

PMC · DOI: 10.3389/fonc.2025.1606116 · Frontiers in Oncology · 2025-06-25

## TL;DR

A rare case of breast cancer presented with rectal and neck lymph node metastasis before the breast tumor was detected.

## Contribution

This case highlights the unusual presentation of non-mass breast cancer and emphasizes the need for broader diagnostic approaches.

## Key findings

- Breast cancer presented with rectal and cervical lymph node metastasis as initial symptoms.
- Non-specific symptoms delayed early diagnosis of breast cancer.
- Imaging and biopsy are crucial for diagnosing non-mass breast cancer.

## Abstract

It is uncommon for breast cancer to present with distant metastasis as the initial symptom. This study reported a 67-year-old female patient with breast non-mass invasive ductal carcinoma, who sought medical attention due to abdominal distention, lower abdominal pain, constipation, hematochezia, and left-sided neck swelling. After a thorough examination, pathology confirmed the diagnosis of breast invasive ductal carcinoma, along with cervical lymph node and rectal metastasis. The non-specific breast symptoms in this case posed challenges for the early diagnosis of breast cancer. This also suggests that for breast cancer patients without a history of gastrointestinal disease, the presence of changes in bowel habits should raise suspicion for metastatic lesions. Imaging combined with biopsy pathology plays an important role in the diagnosis and treatment of non-mass breast cancer. This case also underscores the importance of breast health awareness and routine breast cancer screening among women, both for clinical practice and public health initiatives. Notably, early identification and diagnosis of non-mass breast cancer, coupled with the development of personalized treatment plans through multidisciplinary collaboration, are essential for enhancing treatment efficacy.

## Linked entities

- **Diseases:** breast cancer (MONDO:0004989)

## Full-text entities

- **Diseases:** lymph node metastasis (MESH:D008207), invasive ductal carcinoma (MESH:D044584), breast cancer (MESH:D001943), constipation (MESH:D003248), node (MESH:D012804), metastasis (MESH:D009362), gastrointestinal disease (MESH:D005767), abdominal distention (MESH:D000007), hematochezia (MESH:D006471), abdominal pain (MESH:D015746), breast invasive ductal carcinoma (MESH:D018270), neck swelling (MESH:D006258)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12237999/full.md

## References

32 references — full list in the complete paper: https://tomesphere.com/paper/PMC12237999/full.md

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Source: https://tomesphere.com/paper/PMC12237999