# Impact of the microcystic, elongated, and fragmented invasion pattern on prognosis in endometrial carcinoma: a comprehensive meta-analysis

## TL;DR

This study finds that a specific tumor invasion pattern in endometrial cancer is linked to worse survival and higher lymph node spread, but the effect is not strong enough to be significant after adjusting for other factors.

## Contribution

A comprehensive meta-analysis of the MELF invasion pattern's impact on prognosis in endometrial carcinoma.

## Key findings

- MELF pattern is associated with increased lymph node metastasis (OR 3.52).
- Univariate analysis shows MELF pattern correlates with worse overall and disease-free survival.
- Multivariate analysis does not confirm a significant association with survival outcomes.

## Abstract

The prognostic significance of the microcystic, elongated, and fragmented (MELF) invasion pattern in endometrial carcinoma (EC) has not been fully elucidated. This study conducted a systematic search across five electronic databases (PubMed, EMBASE, Cochrane, Web of Science, and the Chinese National Knowledge Infrastructure (CNKI)) from inception to April 2025. Assessment focused on overall survival (OS), disease-free survival (DFS), lymph node metastasis (LNM), and recurrence rate (RR) as primary outcomes. Meta-analysis calculations of overall odds ratios (ORs) and hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) elucidated the impact of the MELF pattern on clinical outcomes. Analysis of 18 studies involving 5587 participants revealed a significant correlation between the presence of MELF pattern and heightened LNM incidence (OR 3.52, 95% CI: 2.17–5.71, p < 0.001). Univariate analysis indicated a notable inverse relationship between MELF pattern and OS (HR 2.31, 95% CI: 1.67–3.21, p < 0.001), as well as DFS (HR 1.67, 95% CI: 1.20–2.30, p = 0.002). In multivariate analysis, however, this association did not achieve statistical significance (for OS, HR 1.54, 95% CI: 0.99–2.41, p = 0.056; for DFS, HR 1.25, 95% CI: 0.90–1.74, p = 0.191). The findings of this meta-analysis demonstrated that the MELF pattern was linked to elevated risk of LNM and poorer OS and DFS outcomes. The correlation was influenced by various factors including surgical interventions and adjuvant therapies. While potentially increasing the risk of recurrence, the findings did not demonstrate statistical significance (OR 1.15, 95% CI: 0.61–2.16; p = 0.669).