# Molecular entities for the anti-melanoma effect of Solanum nigrum

## TL;DR

This paper identifies specific compounds in Solanum nigrum that may help fight melanoma by targeting certain genes.

## Contribution

The study discovers two unique active compounds in Solanum nigrum and their associated gene targets for melanoma.

## Key findings

- Solanum nigrum has two active ingredients, diosgenin and solanocapsine, with anti-melanoma properties.
- Three gene targets (CYP3A4, GBA2, and PTK6) are associated with the anti-melanoma effect of these compounds.

## Abstract

Prognosis for advanced and metastatic melanoma remains poor despite low incidence rate and early diagnosis. A significant number of
melanoma patients use complementary and alternative medicines during their normal treatments in anticipating improving therapeutic
efficacy. Solanum nigrum shows effective inhibitory activity against melanoma cells compared to Hedyotis
diffusa, Scutellaria barbata, and Lobelia chinensis. Therefore, it is of interest to explore
the anti-melanoma entities of S. nigrum. Our data show that three unique melanoma-related gene targets (CYP3A4, GBA2
and PTK6) for two unique active ingredients (diosgenin and solanocapsine) present in S. nigrum have potential role.