# Effect of radiation exposure on oral mucosal cells: An in vitro study

## TL;DR

This study shows that radiation exposure harms oral mucosal cells, with higher doses causing more damage and lower cell survival.

## Contribution

The study quantifies the dose-dependent impact of radiation on oral mucosal cell survival and DNA damage using in vitro methods.

## Key findings

- Cell survival dropped to 40.8% at 8 Gy radiation compared to 98.6% in controls.
- DNA damage increased with higher radiation doses, as shown by the Comet assay.
- Radiation significantly weakens the defense capacity of oral mucosal tissues.

## Abstract

Radiation generates toxic reactions and DNA damage in oral mucosal cells which depends on the exposure dose during laboratory tests.
The survival rate of cells dropped from 98.6% in non-irradiated controls to 40.8% at 8 Gy while both structural cell alterations and DNA
damage manifestations became evident. The extent of DNA damage in cells increased as radiation doses became higher according to findings
from the Comet assay. Radiation produces marked impact on the defense capacity of oral tissues. Protective measures must be implemented
as an essential way to prevent damage to oral mucosa tissues exposed to radiation.