# Omentin level in serum and gingival crevicular fluid following non-surgical periodontal therapy among Rheumatoid Arthritis patients

**Authors:** Geetha Ari, Jyothi Mohit, Komal Vilas, Thirumagal K., Vaishali Kamak R., Anitha Logaranjani, Jaideep Mahendra

PMC · DOI: 10.6026/973206300210623 · Bioinformation · 2025-04-30

## TL;DR

This study examines how non-surgical periodontal therapy affects omentin levels in patients with periodontitis and rheumatoid arthritis.

## Contribution

The novelty lies in evaluating omentin as a potential anti-inflammatory marker in periodontal therapy outcomes among rheumatoid arthritis patients.

## Key findings

- Non-surgical periodontal therapy significantly improved periodontal parameters.
- Omentin levels in serum and gingival crevicular fluid did not show significant changes.
- Omentin may not be a reliable anti-inflammatory marker in this context.

## Abstract

Non-surgical periodontal therapy on serum and gingival crevicular fluid levels of omentin among periodontitis subjects with and
without Rheumatoid Arthritis is of interest. Hence, 33 patients were selected and divided into three groups: P group, RA group and RA+P
group. Periodontal parameters were recorded; samples of serum and gingival crevicular fluid were obtained to evaluate Omentin levels.
All of them showed non-surgical periodontal therapy and were recalled after 6 weeks. The mean change in periodontal parameters from T0
to T1 was statistically significant but serum and gingival crevicular fluid levels of omentin were not statistically significant for
considering it as an anti-inflammatory marker.

## Linked entities

- **Proteins:** ITLN1 (intelectin 1)
- **Diseases:** Rheumatoid Arthritis (MONDO:0008383), periodontitis (MONDO:0005076)

## Full-text entities

- **Genes:** ITLN1 (intelectin 1) [NCBI Gene 55600] {aka HL-1, HL1, INTL, ITLN, LFR, hIntL}
- **Diseases:** inflammatory (MESH:D007249), Rheumatoid Arthritis (MESH:D001172), periodontitis (MESH:D010518)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

25 references — full list in the complete paper: https://tomesphere.com/paper/PMC12236561/full.md

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Source: https://tomesphere.com/paper/PMC12236561