# Cytotoxic and apoptotic effects of novel phytochemical extracts on oral squamous cell carcinoma cells

## TL;DR

This study explores how new plant-based chemicals can reduce survival and increase cell death in oral cancer cells.

## Contribution

The study introduces novel phytochemical extracts that significantly induce apoptosis in oral squamous cell carcinoma cells.

## Key findings

- Cell survival decreased from 85% to 40% with phytochemical treatment.
- Apoptotic death increased from 15% to 60% in treated cells.
- Caspase-3 activation confirmed apoptotic changes in cells.

## Abstract

The oral squamous cell carcinoma has inadequate treatment methods. Therefore, it is of interest to investigate the effect of new
phytochemical extracts on both cell death and programmed cell death of OSCC cells. The phytochemical extracts tested at different
concentrations produced a decrease in cell survival which dropped from 85% to 40% (p < 0.05) and led to increased apoptotic death
from 15% to 60%. Caspase-3 activation tests showed both apoptotic changes and morphological developments at the cellular level for
further consideration through in vivo analysis.