# Bone regeneration using PRF, PRP and β-TCP in bone defects

## TL;DR

This study compares bone regeneration using PRF, PRP, and β-TCP, finding PRF most effective in promoting bone healing.

## Contribution

PRF shows superior bone fill and trabecular density compared to PRP and β-TCP in bone defects.

## Key findings

- PRF achieved 85% bone fill over 12 weeks, outperforming PRP (75%) and β-TCP (65%).
- Histological analysis showed higher trabecular bone density with PRF treatment (p < 0.05).
- PRF's sustained growth factor release enhances bone tissue formation.

## Abstract

Bone regeneration using platelet-rich fibrin (PRF), platelet-rich plasma (PRP) and beta-tricalcium phosphate (β-TCP) in bone
defects is of interest. PRF achieved the maximum bone fill (85%) during the 12 weeks assessment period while PRP and β-TCP reached
75% and 65% bone fill, respectively. Trabecular bone density proved superior in defects treated with PRF according to the histological
findings (p < 0.05). The prolonged availability of growth factors from PRF resulted in better bone tissue formation. The biomaterial
PRF demonstrates strong potential to become an effective solution for efficient bone healing in clinical medicine.