# “One-stop” combined percutaneous left atrial appendage and atrial septal defect closure in atrial fibrillation: safety and feasibility from a single-center cohort

## TL;DR

A combined procedure to close the left atrial appendage and atrial septal defect in atrial fibrillation patients is safe and effective, reducing stroke risk without major complications.

## Contribution

Demonstrates the safety and feasibility of a one-stop combined procedure for LAAC and ASD closure in AF patients.

## Key findings

- All 40 procedures were technically successful with no major complications during follow-up.
- Peri-device leak occurred in 47.5% of patients, but only one case of device-related thrombus was observed and resolved.
- The combined approach is effective for stroke prevention in AF patients with ASD who cannot take long-term anticoagulation.

## Abstract

Patients with atrial fibrillation (AF) and atrial septal defect (ASD) face elevated thromboembolic risks, yet evidence on combined left atrial appendage closure (LAAC) and ASD closure remains limited. We aimed to assess the feasibility and safety of a “one-stop” strategy for simultaneous LAAC and ASD closure.

A retrospective analysis included 40 patients with non-valvular AF and ASD undergoing combined procedures (2016–2024). Procedural success, complications, and long-term outcomes (mean follow-up: 1,194.3 days) were analyzed.

All procedures were technically successful. No major complications (stroke, device embolization, or death) occurred during follow-up. Peri-device leak (PDL) was observed in 19 patients (47.5%), with only one case of device-related thrombus (resolved with anticoagulation).

The “one-stop” approach is a safe and effective strategy for stroke prevention in AF patients with ASD, particularly those unsuitable for long-term anticoagulation.