# PROTOCOL: PrEP (Non)Adherence Among Men Who Have Sex With Men: An Overview of Reviews: A Systematic Review

**Authors:** Guilherme G. Pinheiro, Carla Moleiro, David L. Rodrigues

PMC · DOI: 10.1002/cl2.70047 · 2025-07-07

## TL;DR

This paper outlines a systematic review protocol to understand factors affecting PrEP adherence among men who have sex with men.

## Contribution

It introduces a structured overview of reviews to identify facilitators, barriers, and research gaps in PrEP use among MSM.

## Key findings

- The review will aggregate findings from multiple overviews to understand PrEP awareness and adherence factors.
- It aims to identify gaps in the literature on facilitators and barriers to PrEP uptake and adherence.
- The study aligns with Sustainable Development Goal 3.3 to end the AIDS epidemic.

## Abstract

This is the protocol for a Campbell systematic review. The objectives are as follows. The proposed overview of reviews aims to: (1) aggregate and systematize findings from multiple overviews of reviews, and offer a broader understanding of the factors, both facilitators and barriers related to PrEP awareness, uptake, and adherence among MSM; and (2) understand if there are gaps in the literature on potential facilitators and barriers that need greater analysis. Hence, the purpose of this overview of reviews aligns with Sustainable Development Goal 3 of the 2030 Agenda for Sustainable Development, particularly with SDG 3.3, that is, end the epidemics of AIDS and other communicable diseases.

## Linked entities

- **Diseases:** AIDS (MONDO:0012268)

## Full-text entities

- **Diseases:** AIDS (MESH:D000163), communicable diseases (MESH:D003141)
- **Chemicals:** PrEP (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC12230767