Ticagrelor-Induced Dermatological Hypersensitivity Reaction

TL;DR

A 64-year-old man developed a skin rash after starting ticagrelor, which resolved when the drug was stopped and replaced with clopidogrel.

Contribution

This case report documents a rare ticagrelor-induced dermatological hypersensitivity reaction.

Findings

A diffuse erythematous rash occurred two days after ticagrelor initiation.

The rash resolved after discontinuing ticagrelor and switching to clopidogrel with corticosteroids and antihistamines.

Abstract

Ticagrelor, a potent antiplatelet medication widely used in acute coronary syndromes, is known for its favourable efficacy and safety profile as compared to clopidogrel. However, skin-related adverse events associated with ticagrelor are rare and not extensively reported in the literature. Here we present a 64-year-old male with a history of coronary artery disease and recent ticagrelor initiation following percutaneous coronary intervention. The patient developed a diffuse erythematous rash involving the trunk and extremities, two days post-ticagrelor initiation, prompting a thorough evaluation for drug-induced hypersensitivity reactions. The rash resolved upon discontinuation of ticagrelor and initiation of clopidogrel therapy along with corticosteroids and antihistamines. This case highlights the importance of recognizing dermatology adverse events associated with ticagrelor.

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