Innovative Multilayered Electrospun Fiber Systems for Dual-Action HIV Prophylaxis and Nonhormonal Contraception
Deborah A. Ogundemuren, Peace-Ofonabasi O. Bassey, Karamot O. Oyediran, Ohakwe G. Nmesoma, Dimitrios Tsamos, Alkiviadis Tsamis, Alexander E. Tsouknidas, Andrew N. Amenaghawon, Chukwuemeka P. Azubuike, Margaret O. Ilomuanya
TL;DR
This study develops a multilayered fiber system that can deliver HIV prevention and contraceptive drugs in a single, on-demand dosage.
Contribution
A novel multilayered electrospun fiber system for dual-action HIV prophylaxis and nonhormonal contraception is introduced.
Findings
The system achieved 52.13% encapsulation efficiency for tenofovir and 63.86% for nifedipine.
The top layer showed pH-responsive release, while the backing layer exhibited near-zero-order release.
The fibers demonstrated Fickian diffusion in simulated vaginal fluid environments.
Abstract
Background: Electrospun fiber drug delivery systems, integrated into multipurpose prevention technologies, offer a promising solution for women facing health risks from HIV/STIs and unmet contraceptive needs by providing on-demand protection in a single dosage form. This study investigates the potential of a multilayer electrospun fiber construct for pH-responsive and sustained release of the HIV microbicide tenofovir (TFV) and the CatSper channel blocker nifedipine (NFP) respectively. Method: Electrospun fibers were fabricated in a stacked architecture by blend electrospinning using polycaprolactone (PCL) as the backing layer for delivering NFP and cellulose acetate phthalate (CAP) as the top layer for delivering TFV. An analysis of surface morphology, mechanical and chemical properties, mucoadhesion, drug release profiles, encapsulation efficiency, and safety assessments was…
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Taxonomy
TopicsElectrospun Nanofibers in Biomedical Applications · HIV/AIDS oral health manifestations · Advanced Drug Delivery Systems