Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery
Hai Jiang, Zhipeng Xu, Qi Song, Junjie Tao, Jia Liu, Qiang Wang, Huaisheng Zhang, Heng Zhu, Qiliang Li, Lei Li
TL;DR
This study shows that inhibiting PFKFB3 using nanovesicles can restore glucose metabolism and reduce inflammation in acute pancreatitis.
Contribution
The study introduces nanovesicle-based PFKFB3 inhibition as a novel therapeutic strategy for metabolic complications in acute pancreatitis.
Findings
PFKFB3 inhibition via nanovesicles restored glycolytic function and improved glucose metabolism in AP models.
Nanovesicle delivery reduced inflammation and metabolic disturbances in acute pancreatitis.
PFKFB3 is identified as a key therapeutic target for glucose metabolism disorders in AP.
Abstract
Acute pancreatitis (AP) is a severe inflammatory disease frequently accompanied by disturbances in glucose metabolism, which further complicate the disease prognosis. This study aims to explore the role of PFKFB3, a key glycolytic enzyme, in regulating glucose metabolism in AP and assess the potential of PFKFB3 inhibition via nanovesicle delivery to mitigate metabolic dysfunction. Transcriptomic data from Gene Expression Omnibus (GEO), including single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing, were analyzed to investigate the molecular mechanisms involved in glucose metabolism dysregulation in AP. The therapeutic effects of PFKFB3 inhibition via nanovesicle-based delivery were evaluated using both in vivo and in vitro AP models. PFKFB3 inhibition significantly restored normal glycolytic function and improved glucose metabolism in AP models. Moreover,…
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Taxonomy
TopicsPancreatitis Pathology and Treatment · Pancreatic and Hepatic Oncology Research · Pancreatic function and diabetes