Pancreatic Plasmacytoma Presenting as Acute Pancreatitis: An Unusual Extramedullary Onset of Multiple Myeloma
Bakr Alhayek, Xiaowei Malone, Ariba Khan, Raja Gummalla, Ryan Brink
TL;DR
A rare case of multiple myeloma presenting as acute pancreatitis due to a pancreatic plasmacytoma is reported.
Contribution
This case highlights an unusual extramedullary onset of multiple myeloma involving the pancreas.
Findings
A pancreatic plasmacytoma caused acute pancreatitis in a 63-year-old woman.
The case demonstrates extramedullary disease in multiple myeloma with aggressive clinical implications.
Diagnostic criteria for multiple myeloma were met with 15% clonal plasma cells in bone marrow.
Abstract
Multiple myeloma (MM) typically manifests with bone pain, anemia, and hypercalcemia. Extramedullary disease (EMD), particularly pancreatic involvement, is rare. We report a 63-year-old woman presenting with acute pancreatitis secondary to a pancreatic plasmacytoma. Initial symptoms included epigastric pain, elevated lipase (1,389 U/L), and imaging revealing a 12.1 cm pancreatic mass. Biopsy confirmed lambda-restricted plasma cells (CD138+). Bone marrow biopsy showed 15% clonal plasma cells, meeting the diagnostic criteria for MM. EMD in MM signifies aggressive disease and poor prognosis.
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Taxonomy
TopicsMultiple Myeloma Research and Treatments · Pancreatitis Pathology and Treatment · Peripheral Neuropathies and Disorders