# A Case of Cryoglobulinemic Nephritis That Responded to Rituximab Monotherapy

## TL;DR

A 65-year-old woman with cryoglobulinemic nephritis showed improvement after being treated with rituximab alone.

## Contribution

This case demonstrates the potential effectiveness of rituximab monotherapy in treating cryoglobulinemic nephritis.

## Key findings

- Rituximab treatment led to decreased serum creatinine and urinary protein levels.
- Complement lowering was suppressed following rituximab therapy.
- The patient's condition improved without additional therapies.

## Abstract

The patient was a 65-year-old woman with ascites effusion and portal hypertension of unknown cause for the past three years, who was followed up with diuretics. Subsequently, the patient developed abdominal distention and worsening leg edema, and the laboratory test results revealed positive antinuclear antibodies, mild renal impairment, and abnormal urinalysis. After renal biopsy and laboratory tests, the patient was diagnosed with cryoglobulinemic nephritis. She was treated with rituximab monotherapy, which resulted in decreased serum creatinine and urinary protein levels and suppression of complement lowering. Thus, rituximab treatment may be effective for cryoglobulinemic nephritis.