# Plaque-Like CD34-Positive Dermal Fibroma of the Toe: A Case Report and Review of the Literature

## TL;DR

This paper reports the first case of a rare skin tumor called plaque-like CD34-positive dermal fibroma occurring on a toe, which was confirmed through histopathology and literature review.

## Contribution

The first documented case of plaque-like CD34-positive dermal fibroma occurring on the toe.

## Key findings

- Histopathology confirmed the presence of a CD34-positive dermal fibroma on the toe.
- Literature review found no prior reports of this tumor type occurring on the digits.
- The case highlights the diagnostic challenges of plaque-like CD34-positive dermal fibromas.

## Abstract

Plaque-like CD34-positive dermal fibroma (PDF) is a rare, benign cutaneous neoplasm that is most commonly seen on the neck or trunk of young females. Diagnosis of PDF can be challenging due to its clinical heterogeneity and immunohistochemical overlap with other spindle cell neoplasms. We report the case of a 57-year-old female who presented with a painless, slowly enlarging pigmented macule on the dorsal aspect of her left first toe. Histopathologic analysis revealed a proliferation of wavy and spindle-shaped fibroblasts interwoven within the dermis, with immunohistochemistry showing strong CD34 positivity, consistent with a diagnosis of PDF. A comprehensive review of the literature was conducted to evaluate previously reported cases and anatomical distributions of PDFs. This review identified no prior reports of PDF involving the digits. To the best of our knowledge, this is the first documented case of a PDF occurring on the toe.