# Evaluation of an artificial intelligence noise reduction tool for conventional X-ray imaging – a visual grading study of pediatric chest examinations at different radiation dose levels using anthropomorphic phantoms

**Authors:** Maria Hultenmo, Johanna Pernbro, Jenny Ahlin, Martin Bonnier, Magnus Båth

PMC · DOI: 10.1007/s00247-025-06251-0 · Pediatric Radiology · 2025-05-13

## TL;DR

This study shows that an AI-based noise reduction tool improves image quality in pediatric chest X-rays, even at lower radiation doses.

## Contribution

The study evaluates AI noise reduction in pediatric X-ray imaging using phantoms and visual grading by radiologists.

## Key findings

- AI-based INR significantly improved image quality at all dose levels compared to standard noise reduction.
- INR images at 80% or lower dose levels were rated as better than standard images at full dose.
- Similar trends were observed in lateral images, though with fewer significant results.

## Abstract

Noise reduction tools developed with artificial intelligence (AI) may be implemented to improve image quality and reduce radiation dose, which is of special interest in the more radiosensitive pediatric population.

The aim of the present study was to examine the effect of the AI-based intelligent noise reduction (INR) on image quality at different dose levels in pediatric chest radiography.

Anteroposterior and lateral images of two anthropomorphic phantoms were acquired with both standard noise reduction and INR at different dose levels. In total, 300 anteroposterior and 420 lateral images were included. Image quality was evaluated by three experienced pediatric radiologists. Gradings were analyzed with visual grading characteristics (VGC) resulting in area under the VGC curve (AUCVGC) values and associated confidence intervals (CI).

Image quality of different anatomical structures and overall clinical image quality were statistically significantly better in the anteroposterior INR images than in the corresponding standard noise reduced images at each dose level. Compared with reference anteroposterior images at a dose level of 100% with standard noise reduction, the image quality of the anteroposterior INR images was graded as significantly better at dose levels of ≥ 80%. Statistical significance was also achieved at lower dose levels for some structures. The assessments of the lateral images showed similar trends but with fewer significant results.

The results of the present study indicate that the AI-based INR may potentially be used to improve image quality at a specific dose level or to reduce dose and maintain the image quality in pediatric chest radiography.

## Full-text entities

- **Genes:** TFAP2A (transcription factor AP-2 alpha) [NCBI Gene 7020] {aka AP-2, AP-2alpha, AP2TF, BOFS, TFAP2}, JUNB (JunB proto-oncogene, AP-1 transcription factor subunit) [NCBI Gene 3726] {aka AP-1}, AP5B1 (adaptor related protein complex 5 subunit beta 1) [NCBI Gene 91056] {aka AP-5, PP1030}
- **Diseases:** lung nodules (MESH:D003074), INR (MESH:D006317), pneumothorax (MESH:D011030), cancer (MESH:D009369), pneumonia (MESH:D011014), hematological malignancies (MESH:D019337)
- **Chemicals:** AP6 (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12227453/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12227453/full.md

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Source: https://tomesphere.com/paper/PMC12227453