# Research progress on endoplasmic reticulum homeostasis in acute kidney injury

## TL;DR

This paper reviews how endoplasmic reticulum dysfunction contributes to acute kidney injury and explores potential treatments targeting ER homeostasis.

## Contribution

The paper provides a comprehensive review of ER's role in AKI and highlights ER stress inhibitors as novel therapeutic targets.

## Key findings

- ER dysfunction is linked to the progression of acute kidney injury.
- ER stress inhibitors have been identified as potential therapeutic agents.
- Targeting ER homeostasis may offer new treatment strategies for AKI.

## Abstract

The endoplasmic reticulum (ER) is the most metabolically active organelle in cells, and recent research has shown that abnormal ER function is involved in the occurrence and development of acute kidney injury (AKI), but the underlying molecular mechanism needs to be further elucidated. Here, we review the biological functions of the ER in cellular metabolism, explore the current research progress on the role of the ER in different triggers of AKI, and summarize the ER stress inhibitors discovered thus far. Finally, we explore the possibility of targeting ER homeostasis as a therapeutic target for AKI.