# A randomized safety study of tolerance to table rotation in dynamic trajectory radiotherapy in healthy volunteers

## TL;DR

A study found that dynamic trajectory radiotherapy does not cause more motion sickness than standard radiotherapy in healthy volunteers.

## Contribution

The study demonstrates non-inferiority of dynamic trajectory radiotherapy in terms of motion sickness compared to non-coplanar VMAT.

## Key findings

- Only one symptomatic motion sickness case occurred over 164 dry runs.
- Both techniques increased motion sickness scores, but DTRT was non-inferior to ncVMAT.

## Abstract

•Motion sickness in Dynamic Trajectory Radiotherapy was non-inferior to non-coplanar VMAT.•Over 164 dry runs of both techniques, only one symptomatic motion sickness occurred.•Yet, both techniques led to increased motion sickness scores in questionnaires.

Motion sickness in Dynamic Trajectory Radiotherapy was non-inferior to non-coplanar VMAT.

Over 164 dry runs of both techniques, only one symptomatic motion sickness occurred.

Yet, both techniques led to increased motion sickness scores in questionnaires.

This study aimed to show that table movement of dynamic trajectory radiotherapy (DTRT) does not induce more motion sickness than standard-of-care non-coplanar volumetric modulated arc therapy (ncVMAT). Forty-one healthy volunteers underwent dry-runs of DTRT and ncVMAT in four different, randomly allocated sequences. The primary outcome was the Motion Sickness Assessment Questionnaire (MSAQ) summary score. The average change in MSAQ summary score before to after dry-runs was 1.88 for DTRT and 1.62 for ncVMAT. The difference between both techniques was 0.26 [95% CI: −0.24 to 0.75]; the CI demonstrated non-inferiority of DTRT to ncVMAT for motion sickness in healthy volunteers.