# MDT: A simple tool to facilitate dropcasting on in situ TEM MEMS chips

**Authors:** Matthias Quintelier, Joke Hadermann

PMC · DOI: 10.1016/j.ohx.2025.e00666 · HardwareX · 2025-06-21

## TL;DR

The MDT is a 3D-printable tool that simplifies dropcasting for in situ TEM MEMS chips by reducing contamination and improving sample preparation.

## Contribution

The MDT is a novel, cost-effective, and in-house 3D-printable solution for dropcasting on MEMS chips.

## Key findings

- The MDT confines droplets to a specific area, preventing particle migration under the O-ring.
- It reduces contamination risks at the inlet and outlet ports of closed cell chip holders.
- The tool helps avoid failed experiments and lowers experimental costs.

## Abstract

In situ transmission electron microscopy with holders based on the use of micro-electromechanical systems provides valuable insights into material kinetics, yet sample preparation remains complex due to fragile silicon nitride (Si3N4) windows and the risk of leaks and contamination during dropcasting. This results in failed experiments and increases experimental costs. This paper introduces the MEMS Dropcasting Tool (MDT), a cost-effective, in-house 3D-printable solution that confines the droplet to a specific area, preventing particle migration under the O-ring and reducing contamination risks at the inlet and outlet ports of closed cell chip holders.

## Linked entities

- **Chemicals:** silicon nitride (PubChem CID 3084099), Si3N4 (PubChem CID 3084099)

## Full-text entities

- **Chemicals:** Si3N4 (MESH:C032734)

## Full text

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## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12226395/full.md

## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12226395/full.md

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Source: https://tomesphere.com/paper/PMC12226395