# Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Triggered by Heat Stroke: A Case Report

## TL;DR

This paper reports the first case of a hormone disorder caused by heat stroke, highlighting the need for careful monitoring in such patients.

## Contribution

The paper presents the first documented case linking heat stroke to SIADH, offering new insights into their potential physiological connection.

## Key findings

- A 50-year-old man developed SIADH following heat stroke with no prior medical history.
- Neuroinflammation and oxidative stress in the hypothalamus are proposed as mechanisms linking heat stroke to SIADH.
- The case underscores the importance of monitoring for SIADH in patients with heat-related illnesses.

## Abstract

We present the first documented case of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) triggered by heat stroke in a man in his mid-50s with no medical history. After experiencing acute symptoms during a heatwave, he was hospitalized. The absence of dehydration and the presence of hyponatremia, along with other laboratory findings, fulfilled the diagnostic criteria for SIADH once other causes were excluded. The linkage between heat stroke and SIADH is thought to involve neuroinflammation and oxidative stress in the hypothalamus, which impacts antidiuretic hormone (ADH) production and secretion. This case highlights critical considerations for emergency and post-acute care in heat-related illnesses, emphasizing the need for vigilant monitoring of SIADH symptoms in patients experiencing heat stroke.