# A Challenging Diagnosis of Gliosarcoma: A Case Report

**Authors:** Ioannis P Athinodorou, Kyprianos Kolios, Dimitra Koumoundourou, Constantine Constantoyannis

PMC · DOI: 10.7759/cureus.85292 · Cureus · 2025-06-03

## TL;DR

This case report describes a rare brain tumor called gliosarcoma that was initially mistaken for a metastasis or glioblastoma.

## Contribution

The paper highlights the diagnostic challenge of gliosarcoma and its similarity to other brain tumors.

## Key findings

- A 74-year-old patient was diagnosed with gliosarcoma after initial suspicion of brain metastasis or glioblastoma.
- Gliosarcoma's radiological features can closely resemble those of glioblastoma or metastatic tumors.
- Histopathological examination is essential for accurate diagnosis of gliosarcoma.

## Abstract

Gliosarcoma (GS) is a rare variant of glioblastoma (GBM) that usually affects middle-aged adults. The radiological characteristics of GS are similar to the radiological features observed in GBM. We present the case of a 74-year-old male patient who presented with neurological symptoms associated with a brain tumor. The patient had a medical history of prostate cancer, and MRI findings suggested the diagnosis of brain metastasis or GBM. However, postoperative histopathological examination of the tissue specimen confirmed a diagnosis of GS. GS can mimic several entities and should be included in the differential diagnosis of metastasis-like brain masses.

## Linked entities

- **Diseases:** gliosarcoma (MONDO:0016681), glioblastoma (MONDO:0018177), prostate cancer (MONDO:0005159)

## Full-text entities

- **Diseases:** GBM (MESH:D005909), GS (MESH:D018316), brain masses (MESH:C536030), brain tumor (MESH:D001932), brain metastasis (MESH:D009362), prostate cancer (MESH:D011471)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12225694/full.md

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12225694/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12225694/full.md

---
Source: https://tomesphere.com/paper/PMC12225694