# The effect of COVID-19 vaccination on serum levels of anti-Müllerian hormone in women of reproductive age

## TL;DR

This study found that receiving AstraZeneca or CoronaVac vaccines did not affect anti-Müllerian hormone levels in women of reproductive age.

## Contribution

The study provides evidence that common COVID-19 vaccines do not negatively impact AMH levels in reproductive-age women.

## Key findings

- AMH levels remained stable after up to three doses of AstraZeneca® or CoronaVac® vaccines.
- No significant differences in AMH were observed between age subgroups or those with/without prior COVID-19 exposure.
- Statistical analysis showed no adverse effects of vaccination on AMH in the studied population.

## Abstract

To evaluate the effects of COVID-19 vaccination
(AstraZeneca® and CoronaVac®) on
anti-Müllerian hormone (AMH) levels in threatened women.

Retrospective cohort study evaluating serum AMH before and up to three
vaccination doses against COVID-19 between 2021 and 2022 at FMABC.
Statistical analysis presented in Stata 14. Clinical variables were
described by absolute and relative frequency, in addition to measures of
central tendency and dispersion. Shapiro-Wilk test for normality. Continuous
variables compared within the group using the Friedman test and, between
groups, Mann-Whitney U tests (non-parametric); Chi-square and Fisher’s exact
tests, for categorical variables, with p<0.05.

Median age of the 38 volunteers was 24 years (p25-75: 22-30) and AMH levels
(ng/dl) at times 0, 1, 2 and 3 median (95% CI) were, respectively,
4.6(3.5-6); 4(2.3-5); 4.3(3-5); 4.9(2.6-6.3), p=0.726.
Likewise, there was no statistically significant difference in the
assessments between subgroups aged <35 and ≥35 years old and with
and without exposure to COVID-19 in relation to AMH values.

The vaccination against COVID-19 with the AstraZeneca® and
CoronaVac® vaccines did not indicate any damage to
anti-Müllerian hormone values in women of reproductive age.