# Self-reported beta-lactam allergy, mislabeling and inappropriate antibiotic use: a study from South India

**Authors:** Krishna Suresh, Vettakkara Kandy Muhammed Niyas, Sabeer Hameed, Parvathy Vijayamohan, Rajalakshmi Ananthanarayanan

PMC · DOI: 10.1017/ash.2025.10049 · Antimicrobial Stewardship & Healthcare Epidemiology : ASHE · 2025-06-30

## TL;DR

This study from South India shows that many patients labeled with beta-lactam allergies are actually at low risk, leading to unnecessary use of alternative antibiotics.

## Contribution

The study demonstrates the prevalence of mislabeled beta-lactam allergies and advocates for structured delabeling to improve antibiotic use.

## Key findings

- Over 50% of patients with a penicillin allergy label were classified as low risk.
- 21% of patients with a cephalosporin allergy label were classified as low risk.
- 44% of patients receiving alternative antibiotics due to allergy labels were found to be low-risk.

## Abstract

This study assessed beta-lactam allergy labels in 300 hospitalized adults using validated scores. Over 50% with penicillin and 21% with cephalosporin allergies were classified as low risk. Among those receiving alternative antibiotics due to inappropriate allergy labels, 44% were low-risk. Findings support structured allergy delabeling programs to enhance antimicrobial stewardship.

## Linked entities

- **Chemicals:** beta-lactam (PubChem CID 136721), penicillin (PubChem CID 2349), cephalosporin (PubChem CID 25058126)

## Full-text entities

- **Diseases:** allergies (MESH:D004342)
- **Chemicals:** beta-lactam (MESH:D047090), penicillin (MESH:D010406), cephalosporin (MESH:D002511)

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12224132/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12224132/full.md

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Source: https://tomesphere.com/paper/PMC12224132