# Exosomal proteins: new targets for early diagnosis and treatment of cancer

## TL;DR

This review explores how proteins in exosomes can help detect and treat cancer earlier, offering advantages over traditional blood tests.

## Contribution

The paper highlights the unique potential of exosomal proteins for cancer diagnosis and treatment, compared to conventional methods.

## Key findings

- Exosomal proteins reflect the physiological state of the originating cell and are involved in intercellular communication in cancer.
- Exosomal proteins offer novel opportunities for cancer diagnosis and prognosis.
- They provide distinct advantages over typical serological measurements.

## Abstract

Exosomes are nanoscale, double-membraned vesicles released by a variety of living cells. A wide variety of cargoes, including proteins, DNA and RNA, are transported by exosomes to target cells, thereby transmitting biological signals. In addition to being an essential component of the exosomal cargo, exosomal proteins are a reflection of the physiological state of the originating cell, and play an essential part in intercellular communication in numerous diseases, including cancer. The present review provides a summary of the novel uses of exosomal proteins in cancer diagnosis and prognosis, and highlights the distinct qualities that exosomal proteins possess, when compared with typical serological measurements.