# Comparative Analysis of Clinical and Radiographic Outcomes Using a Combination of Zinc Oxide and Nano-Hydroxyapatite With Ozonated Oil and Endoflas as an Obturating Material in Primary Teeth: A Prospective Study

**Authors:** Souravi Chattopadhyay, Sarmeshta Soni, Deepa Bhatt, Pooja Pani, Aysaiki Maji, Karthikeyan Ramalingam

PMC · DOI: 10.7759/cureus.85213 · Cureus · 2025-06-01

## TL;DR

This study compares two materials for filling primary teeth after root canal treatment, finding one more effective radiographically over nine months.

## Contribution

The study introduces a novel comparison of zinc oxide/nano-hydroxyapatite with ozonated oil versus Endoflas as obturating materials in children's teeth.

## Key findings

- Both groups showed 100% clinical success after nine months.
- Radiographically, Endoflas (group B) had 100% success versus 80% for the zinc oxide mixture (group A).
- Endoflas showed significantly better radiographic outcomes (p < 0.05).

## Abstract

Background

A primary tooth plays a vital role in maintaining oral health and general well-being in children. It is important to maintain its position in the dental arch.

Aim

This study aims to compare the clinical and radiographic success of a mixture of zinc oxide and nano-hydroxyapatite with ozonated oil and Endoflas FS (Sanlor, Cali, Colombia) as an obturating material in primary teeth.

Materials and methods

The study sample consisted of 30 human primary teeth treated with pulpectomy in children aged five to eight years, and it was split into two groups. Group A consisted of 15 teeth that were obturated with a mixture of zinc oxide, nano-hydroxyapatite, and ozonated oil (Adc Inclusive Dentozone India, Raigad, India), and group B consisted of 15 teeth that were obturated with Endoflas FS endodontic sealer. Both the groups were observed based on clinical criteria including presence/absence of pain, swelling, mobility, and tenderness on percussion and radiographic criteria including resorption of the material along with physiological resorption of the root, deviation of the path of eruption of the underlying permanent teeth, and resorption of over-pushed material (if any) at the end of the three-month, six-month, and nine-month periods. Statistical analysis was done using the chi-square test using SPSS version 24 (IBM SPSS Statistics for Windows, IBM Corp., Armonk, NY) to see the significant difference (p < 0.05) of each group.

Result

At the end of nine months, both group A and group B showed a 100% success rate clinically, whereas radiographically, group B showed a 100% success rate and group A showed an 80% success rate, with a significant difference of p < 0.05.

Conclusion

Based on the current study, after the clinical and radiographic evaluation for nine months, Endoflas showed betterresults than the mixture of zinc oxide, nano hydroxyapatite, and ozonated oil.

## Linked entities

- **Chemicals:** zinc oxide (PubChem CID 3007857)

## Full-text entities

- **Diseases:** tenderness (MESH:D063806), swelling (MESH:D004487), pain (MESH:D010146)
- **Chemicals:** hydroxyapatite (MESH:D017886), Endoflas (-), Endoflas FS (MESH:C098568), Zinc Oxide (MESH:D015034)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12221104/full.md

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12221104/full.md

## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC12221104/full.md

---
Source: https://tomesphere.com/paper/PMC12221104