# Conformational Plasticity in Amyloid Assemblies: A Paradigm Shift from Structural Rigidity to Functional Adaptability

## TL;DR

This paper shows how amyloid assemblies can change shape, challenging the idea that they are structurally rigid and suggesting they can adapt functionally.

## Contribution

The study introduces a new perspective on amyloid assemblies by demonstrating their conformational plasticity using advanced imaging techniques.

## Key findings

- hIAPP conformational ensembles vary with mutations and PTMs.
- Scanning tunneling microscopy reveals structural diversity in amyloid assemblies.
- Findings suggest amyloid assemblies are functionally adaptable rather than rigid.

## Abstract

The
divergence of conformational ensembles of hIAPP in response to different
types of mutations and PTMs has been decoded by leveraging
the scanning tunneling microscopy-based probability interpretation
technique.