# Building a Medicinal Chemistry Framework for Bioorthogonal Probes

## TL;DR

This paper explores how to create better fluorescent probes by studying interactions between tetrazine and proteins.

## Contribution

The study introduces a new method for optimizing bioorthogonal probes through tetrazine-protein interactome screening.

## Key findings

- Screening the tetrazine-protein interactome reveals key interactions for probe performance.
- Balancing reactivity and specificity is crucial for high-performance fluorescent probes.

## Abstract

Screening
the tetrazine-protein interactome finds the balance needed
for high-performance fluorescent probes.