# Genomic landscape of virus-associated cancers

## TL;DR

This study compares virus-positive and virus-negative tumors across nine cancer types, revealing distinct genetic and clinical patterns in virus-associated cancers.

## Contribution

The study provides a comprehensive genomic and clinical comparison of virus-positive and virus-negative tumors across multiple cancer types.

## Key findings

- Virus-positive tumors show lower somatic mutation burden and distinct mutation signatures.
- Virus-positive tumors have fewer TP53 and CDKN2A mutations but more DDX3X and EIF4A1 mutations.
- Virus-positivity is linked to higher PD-(L)1 inhibitor response rates and increased T cell infiltration in certain cancers.

## Abstract

It has been estimated that 15%-20% of human cancers are attributable to infections, mostly by carcinogenic viruses. The incidence varies worldwide, with a majority affecting developing countries. Here, we conduct a comparative analysis of virus-positive and virus-negative tumors in nine cancers linked to five viruses. We observe a higher frequency of virus-positive tumors in males, with notable geographic differences in incidence. Our genomic analysis of 1971 tumors reveals a lower somatic burden, distinct mutation signatures, and driver gene mutations in virus-positive tumors. Compared to virus-negative cases, virus-positive cases have fewer mutations of TP53, CDKN2A, and deletions of 9p21.3/CDKN2A-CDKN1A while exhibiting more mutations in RNA helicases DDX3X and EIF4A1. Furthermore, an analysis of clinical trials of PD-(L)1 inhibitors suggests an association of virus-positivity with higher treatment response rate, particularly evident in gastric cancer and head and neck squamous cell carcinoma. Both cancer types also show evidence of increased CD8 + T cell infiltration and T cell receptor clonal selection in virus-positive tumors. These results illustrate the epidemiological, genetic, and therapeutic trends across virus-associated malignancies.

Virus-associated cancers remain prevalent worldwide, particularly in developing countries. Here, the authors analyse epidemiological, genetic, and therapeutic trends across nine types of virus-associated cancers, finding that virus-positive tumours are associated with specific demographic and mutational features as well as treatment response rates.