# Towards individualised treatment of urinary tract infections

## TL;DR

This paper suggests using urine biomarkers and drug levels to personalize antibiotic treatment for urinary tract infections.

## Contribution

The novel idea is using existing technologies to monitor biomarkers and drug levels for individualized antibiotic dosing.

## Key findings

- Longitudinal monitoring of urinary biomarkers can support personalized antimicrobial therapy.
- Linking biomarkers with drug levels enables real-time pharmacokinetic-pharmacodynamic optimization.
- Existing technologies can be used for individualized PK-PD optimization in UTIs.

## Abstract

Monitoring host- and pathogen-specific biomarkers alongside drug levels at the site of infection offers promise for personalised antimicrobial therapy. Here, we highlight the potential of longitudinally monitoring biomarkers in urine using existing technologies to enable individualised PK-PD optimisation in urinary tract infections.

Stadler et al. propose using existing technologies to link urinary biomarkers and antimicrobial drug levels for personalised treatment of urinary tract infections. This approach aims to enable real-time pharmacokinetic-pharmacodynamic monitoring and optimise individual antibiotic dosing.