# Histologic Study of Abdominal Skin Treated With Mechanical Dermal Micro‐Coring Technology for Minimally Invasive Skin Removal

## TL;DR

This study examines how a skin-tightening technology called MCT affects skin and tissue, showing increased collagen without scarring.

## Contribution

The study provides new histological evidence of collagen stimulation and dermal homogenization from MCT treatments in humans.

## Key findings

- MCT treatments increased new collagen production in all tested samples.
- No inflammation or scarring was observed after MCT treatments.
- Dermal homogenization occurred in treated areas following MCT use.

## Abstract

Mechanical Dermal Micro‐Coring Technology (MCT; Ellacor System) achieves skin tightening and wrinkle reduction through direct mechanical excision of skin cores using hollow needles and collagen stimulation via the wound‐healing response.

To evaluate histopathology and immunohistochemistry of the skin and subcutaneous tissue after a single and multiple treatments with MCT.

In this single‐center pilot study, 6 female patients scheduled to undergo abdominoplasty were divided into 2 cohorts. Subjects in cohort 1 (safety cohort) received 1 MCT treatment at a depth of 4 mm, 5 mm, and 7 mm, each administered at 1 of 3 unique test areas, with tissue sampling/abdominoplasty 30 days after treatment. Subjects in cohort 2 received 1, 2, or 3 4 mm‐depth treatments at 1 of 3 unique test sites, with 30‐day intervals for > 1 treatment. Tissue sampling/abdominoplasty occurred 90 days after initial treatment. Histopathology was performed at a central laboratory, and biopsies were evaluated using H&E, Herovici, and Movat stains by blinded evaluators.

A robust increase in new collagen compared to the control tissue was observed for 1 to 3 treatments in all samples. There was no evidence of inflammation or scarring, consistent with earlier preclinical and clinical histology.

MCT‐associated histological changes confirm that in addition to skin removal, treatment results in an increase in collagen and homogenization of the dermis in the treated area.