Corrigendum to “Physical Performance and Activity in Older Prostate Cancer Survivors in Comparison with Population-based Matched Controls” [Eur. Urol. Open Sci. 71 (2025) 85–95]

Abstract

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On February 21, 2025, the HUNT Study’s team of researcher’s informed us of an error in their data on grip strength in HUNT participants. The error resulted in a deviation of 1 to 9 kg grip strength, compared to the original data. In response to the error, the team provided us with a new dataset containing updated values for the variable for our matched population-based controls. To determine whether this error affected our published results (Sletten et al. European Urology Open Science, 2025 [accepted for publication Nov. 2024]), we reran our analyses for grip strength with unadjusted and adjusted linear mixed models to compare cancer survivors and controls. We found that the differential directionality between survivors and matched controls remained unchanged and as previously published, with slightly poorer grip strength among survivors. The RC, however, was less in the updated calculations than the RC initially reported. Furthermore, with respect to sensitivity analyses (i.e., separate analyses for survivors having received RARP and survivors having received EBRT, respectively), the difference between survivors and controls was statistically significant in the RARP subgroup only, that is, there was no longer any significant difference between survivors and controls in the EBRT subgroup (see Tables A1, A2, AS1 and AS2).

Because the differences in grip strength identified in the published analyses were slight and of uncertain clinical significance (Eur Urol Open Sci 2025 Vol. 71, p 93), we find that the revealed error does not affect our conclusions.

Table A1. Results from updated dataset provided from the HUNT Study’s team of researchers. Descriptive statistics for outcome variables. Numbers are means (standard deviations (SDs)) if not otherwise specified. Values that deviate from the originally published values in bold italic.OutcomeControls(n = 327)Survivors(n = 109)Primary outcome, mean (SD)SPPB summary score10.6 (1.8)10.5 (2.0)Secondary outcomes, mean (SD)Grip strength (kg) (n = 325 + 109)41.8 (9.0)38.6 (7.2)One-legged balance (sec) (n = 324+101)14.6 (11.2)11.8 (10.1)Gait speed (m/s) (n = 326+109)1.0 (0.3)1.0 (0.2)Physical Activity Index (n = 318+107)3.5 (3.0)3.4 (3.1)**Explorative outcome, mean (SD)Physical function (QLQ-C30) (n = 0+107)NA85.9 (17.6)Table A2. Results from updated dataset provided from the HUNT Study’s team of researchers. Linear mixed model comparing controls and cancer survivors for primary and secondary outcomes, unadjusted and adjusted analyses (RC=regression coefficient; CI=confidence interval). Values that deviate from the originally published values in bold italic.Unadjusted modelAdjusted modelRC (95% CI)p-valueRC (95% CI)p-valueSPPB summary score (n = 382)Control – ref.00Survivor−0.31 (−0.71; 0.09)0.132−0.38 (−0.77; 0.01)0.057Cohabitant status, Living with others^1^0.78 (0.22; 1.35)0.0060.78 (0.21; 1.35)0.007Comorbidities^1^−0.11 (−0.22; −0.007)0.037−0.11 (−0.22; −0.01)0.033Grip strength (kg) (n = 381)Control – ref.00Survivor−3.79 (−5.35;−2.23)<0.001−4.11 (−5.70;−2.51)<0.001Cohabitant status, Living with others^1^1.24 (−0.77; 3.26)0.2771.33 (−0.68; 3.35)**0.195Comorbidities^1^−0.67 (−1.22; −0.12)0.017−0.68 (−1.22; −0.14)**0.013One-legged balance (s) (n = 372)**Control – ref.00Survivor−3.49 (−5.86; −1.13)0.004−4.36 (−6.72; −2.00)<0.001Cohabitant status, Living with others^1^2.97 (−0.02; 5.96)0.0513.03 (0.01; 6.05)0.049Comorbidities^1^−1.49 (−2.15; −0.83)<0.001−1.50 (−2.14; −0.86)<0.001Gait speed (m/s) (n = 382)Control – ref.00Survivor−0.02 (−0.07; 0.02)0.284−0.04 (−0.08; 0.008)0.106Cohabitant status, Living with others^1^0.10 (0.04; 0.16)0.0010.10 (0.04; 0.16)0.002Comorbidities^1^−0.02 (−0.03; −0.007)0.003−0.02 (−0.03; −0.008)0.002Physical Activity Index (n = 375)**Control – ref.00Survivor−0.05 (−0.66; 0.56)0.867−0.14 (−0.75; 0.47)0.648Cohabitant status, Living with others^1^0.48 (−0.26; 1.22)0.2050.49 (−0.26; 1.25)0.198Comorbidities^1^−0.15 (−0.36; 0.06)0.165−0.15 (−0.36; 0.06)0.161Due to missing values on several confounders, the number of survivors and controls with results available for analysis (n) was lower than expected.

^1^Pair (control vs. case) variable is present in these models.

RC = regression coefficient; CI = confidence interval; SPPB = short physical performance battery; PA Index = physical activity index.

*significance level p <0.05.

Table AS1 Strata RARP. Results from updated dataset provided from the HUNT Study’s team of researchers. Linear mixed model comparing cancer survivors previously treated with RARP with their matched controls for primary and secondary outcomes, unadjusted and adjusted analyses (RC=regression coefficient; CI=confidence interval). Updated dataset Values that deviate from the originally published values in bold italic.Unadjusted modelAdjusted modelRC (95% CI)p-valueRC (95% CI)p-valueSPPB summary score (n = 236)Control – ref.00Survivor−0.10 (−0.55; 0.35)0.669−0.16 (−0.59; 0.27)0.471Cohabitant status, Living with others0.99 (0.18; 1.80)0.0170.98 (0.16; 1.79)0.019Comorbidities−0.08 (−0.22; 0.05)0.214−0.07 (−0.20; 0.05)0.238Grip strength (kg) (n = 235)Control – ref.00Survivor***−4.72 (−6.49;−2.95)<0.001−5.23 (−7.06;−3.40)<0.001Cohabitant status, Living with others0.04 (−2.14; 2.32)0.9370.13 (−2.00; 2.26)0.904Comorbidities−0.77 (−1.39****−0.16)0.013−0.77 (**−1.39;−0.16)0.013One-legged balance (s) (n = 232)**Control – ref.00Survivor−4.20 (−7.25; −1.14)0.007−5.28 (−8.42; −2.14)0.001Cohabitant status, Living with others1.32 (−1.89; 5.53)0.5391.22 (−2.76; 5.20)0.548Comorbidities*−1.45 (−2.39; −0.51)0.002−1.45 (−2.36; −0.54)0.002Gait speed (m/s) (n = 236)Control – ref.00Survivor−0.02 (−0.08; 0.04)0.439−0.04 (−0.10; 0.01)0.136Cohabitant status, Living with others0.15 (0.06; 0.23)<0.0010.14 (0.06; 0.23)0.001Comorbidities−0.03 (−0.04; −0.009)0.003−0.03 (−0.04; −0.009)0.002Physical Activity Index (n = 233)**Control – ref.00Survivor0.14 (−0.59; 0.87)0.712−0.08 (−0.84; 0.68)0.843Cohabitant status, Living with others0.39 (−0.68; 1.46)0.4740.37 (−0.70; 1.44)0.500Comorbidities−0.30 (−0.52; −0.09)0.006−0.30 (−0.52; −0.08)0.007*Pair (control vs. case) variable is present in these models.

Table AS2 strata EBRT. Results from updated dataset provided from the HUNT Study’s team of researchers. Linear mixed model comparing cancer survivors previously treated with EBRT with their matched controls for primary and secondary outcomes, unadjusted and adjusted analyses (RC = regression coefficient; CI = confidence interval). Values that deviate from the originally published values in bold italic.Unadjusted modelAdjusted modelRC (95% CI)p-valueRC (95% CI)p-valueSPPB summary score (n = 146)Control – ref.00Survivor−0.67 (−1.42; 0.08)0.081−0.70 (−1.44; 0.04)0.065Cohabitant status, Living with others0.46 (−0.29; 1.20)0.2290.48 (−0.27; 1.24)0.211Comorbidities−0.11 (−0.29; 0.06)0.198−0.12 (−0.29; 0.05)0.167Grip strength (kg) (n = 146)Control – ref.00Survivor***−2.40 (−5.24;−0.44)0.097−2.57 (−5.37; 0.22)*0.071Cohabitant status, Living with others2.98 (−0.23; 6.18)0.0693.05 (−0.21; 6.32)0.067Comorbidities−0.46 (−1.41; 0.49)0.340−0.49 (*****−1.42; 0.45)0.306One-legged balance (s)* (n = 140)Control – ref.00Survivor−2.52 (−6.20; 1.17)0.181−2.96 (−6.74; 0.82)0.125Cohabitant status, Living with others4.69 (1.15; 8.23)0.0094.82 (1.13; 8.51)0.010Comorbidities−1.50 (−2.41; −0.60)0.001−1.54 (−2.42; −0.66)0.001Gait speed (m/s) (n = 146)Control – ref.00Survivor−0.03 (−0.10; 0.04)0.425−0.03 (−0.10; 0.04)0.401Cohabitant status, Living with others0.02 (−0.06; 0.10)0.5850.02 (−0.06; 0.10)0.545Comorbidities−0.008 (−0.03; 0.01)0.380−0.009 (−0.03; 0.009)0.347Physical Activity Index (n = 142)**Control – ref.00Survivor−0.40 (−1.49; 0.69)0.471−0.44 (−1.56; 0.68)0.440Cohabitant status, Living with others0.60 (−0.38; 1.58)0.2280.58 (−0.40; 1.55)0.249Comorbidities0.11 (−0.28; 0.50)0.5760.10 (−0.30; 0.50)0.619*Pair (control vs. case) variable is present in these model.