# Inactivated Mycobacterial Vaccine Nebulized Inhalation: A Effective Therapy for the Prevention and Treatment of Respiratory Diseases?

## TL;DR

Nebulized inactivated mycobacterial vaccines show promise as a therapy for preventing and treating respiratory diseases like asthma and COVID-19.

## Contribution

The paper highlights the effectiveness and mechanisms of nebulized inactivated mycobacterial vaccines in respiratory disease management.

## Key findings

- Nebulized inactivated mycobacterial vaccines stimulate immune responses in the respiratory tract.
- M. vaccae is particularly effective in treating conditions like asthma and RSV.
- The therapy has potential for preventing and treating diseases like sepsis and COVID-19.

## Abstract

Nebulized inhalation therapy is an important method in the prevention and treatment of respiratory diseases, and inactivated mycobacterial vaccine nebulized inhalation has received a wide attention recently, but the roles and mechanisms are still not fully understood. A literature search showed there is a strong scientific rationale and evidence that nebulized inhalation of inactivated mycobacterial vaccine is effective in the prevention and treatment of respiratory diseases. Clinically available mycobacterial vaccines include
Mycobacterium phlei
(M. phlei), BCG, and
Mycobacterium vaccae
(M. vaccae). Nebulized inhalation of inactivated mycobacterial vaccine, especially M. vaccae, has been used in the prevention and treatment of respiratory diseases, such as asthma, respiratory syncytial virus (RSV), coronavirus disease 2019 (COVID‐19), and sepsis. It acts on the respiratory tract directly, thus stimulating the body to produce an immune response, enhance respiratory immunity, and achieve prevention and treatment effects. Nebulized inhalation of inactivated mycobacterial vaccine will be an effective therapy in the prevention and treatment of respiratory diseases.

Nebulized inhalation of inactivated Mycobacterial vaccine will be an effective therapy for the prevention and treatment of respiratory diseases.