# A Case of Primary Urethral Malignant Melanoma With Persistent Bleeding and Severe Anemia

**Authors:** Tatsuma Juichi, Go Noguchi, Yuki Yokoi, Daisuke Yamashita, Shuko Yoneyama, Kazuhide Makiyama, Akitoshi Takizawa

PMC · DOI: 10.1002/iju5.70051 · IJU Case Reports · 2025-05-25

## TL;DR

This paper reports a rare case of primary urethral melanoma in an elderly woman with persistent bleeding and severe anemia.

## Contribution

The novelty lies in documenting a rare clinical case of primary urethral malignant melanoma with persistent bleeding and its management.

## Key findings

- The patient had a fist-sized dark-brown mass extending from the urethra with persistent bleeding.
- Histopathological analysis confirmed primary malignant urethral melanoma.
- Early surgical resection is emphasized for better prognosis despite the disease's aggressiveness.

## Abstract

Primary malignant melanomas of the urethra are extremely rare. The initial symptoms typically include hematuria or genital bleeding. This report describes a case of a massive primary urethral malignant melanoma with persistent bleeding.

An 84‐year‐old woman presented with bleeding and pain from a vulvar mass and severe anemia. She presented with a fist‐sized dark‐brown multifocal mass extending from the urethra, with persistent bleeding and anemia in the same area. After blood transfusion, tumor resection was performed. Histopathological analysis confirmed the presence of primary malignant urethral melanoma.

Urethral malignant melanoma is a rare and aggressive disease that often presents with symptoms that mimic benign conditions. Despite poor prognosis, early surgical resection with adequate margins is crucial. This case highlights the importance of considering malignant melanomas in the differential diagnosis of atypical urethral masses, particularly in patients with persistent bleeding.

## Linked entities

- **Diseases:** malignant melanoma (MONDO:0005105), anemia (MONDO:0002280)

## Full-text entities

- **Diseases:** vulvar mass (MESH:D014845), Urethral Malignant Melanoma (MESH:D008545), pain (MESH:D010146), Anemia (MESH:D000740), urethral masses (MESH:D014522), Bleeding (MESH:D006470), malignant (MESH:D009369), hematuria (MESH:D006417)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12212934/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12212934/full.md

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Source: https://tomesphere.com/paper/PMC12212934